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Assay Kits  >  MMP Assay Kits  >>  SensoLyte® 490 MMP-12 Assay Kit *Fluorimetric*

Product Name SensoLyte® 490 MMP - 12 Assay Kit *Fluorimetric*
Size 1 kit
Catalog # 71137
US$ $601
Description

Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated proteins capable of digesting extracellular matrix components. MMP-12 (macrophage elastase) is implicated in the pathology of many diseases such as emphysema, aortic lesions and cancer. It has recently been shown to play a role in the pathogenesis of rheumatoid arthritis. The SensoLyte® 490 MMP-12 Assay Kit is a complete assay system designed to continuously analyze MMP-12 activity or to screen for MMP-12 inhibitors by using a fluorogenic MMP-12 substrate. The assays are performed in a convenient 96-well or 384-well microplate format. It provides speed, convenience and accuracy in analyzing MMP-12 and in screening MMP-12 inhibitors.

Kit size: 500 assays

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Brochure
Storage -20°C
Product Citations Song, Y. et al. (2013). Expression of matrix metalloproteinase-12 in aortic dissection. BMC Cardiovasc Disord 13, 34. doi:10.1186/1471-2261-13-34
Chan, KH. et al. (2012). Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity. Free Radical Res 46, 1123. doi: 10.3109/10715762.2012.692786
Bogaert, P. et al. (2011). Inflammatory signatures for eosinophilic versus neutrophilic allergic pulmonary inflammation reveal critical regulatory checkpoints. AJP-Lung Physiol doi: 10.1152/ajplung.00202.2010.
Qu, P. et al. (2009). Matrix metalloproteinase 12 overexpression in lung epithelial cells plays a key role in emphysema to lung bronchioalveolar adenocarcinoma transition. Cancer Res 69, 7252.
Takiyama, K. et al. (2009). A Phos-tag-based fluorescence resonance energy transfer system for the analysis of the dephosphorylation of phosphopeptides. Anal Biochem 388, 235.
Ma, X. et al. (2008). Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Mol Genet Metab 94, 298.
Summer, R. et al. (2008). Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol 294, 1035.
Demedts, IK. et al. (2006). Elevated MMP-12 protein levels in induced sputum from patients with COPD. Thorax 61, 196.
     
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