IMG-EN-AS-29906-01-01.jpg
Peptides

[Pyr3]-beta-Amyloid (3-40)

$103.00
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  • Cat.Number : AS-29906-01
  • Availability :
    In production

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A hallmark of Alzheimer's disease (AD) is the presence of beta-Amyloid in plaques in the brains of patients. N-terminally truncated pyroglutamate-modified beta-Amyloid forms such as Aß(3-40) and Aß (11- 40) have been described as major compounds in the senile plaques. Pyro-Glu modified beta-Amyloid forms are more resistant to degradation, show higher toxicity and have increased aggregation propensity compared to non-modified beta-Amyloid.

Specifications

Chemistry
Sequence one letter code
  • Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Sequence three letter code
  • Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
CAS registry number
  • 161818-04-8
Molecular Formula
  • C187H283N51O53S
Molecular Mass/ Weight
  • 4125.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Aβ peptides and calcium influence secretion of the amyloid protein precursor from chick sympathetic neurons in culture

J Neurosci Res . 2000 Aug 15 ; 61(4) 449 | DOI : https://doi.org/10.1002/1097-4547(20000815)61:4<449::AID-JNR12>3.0.CO;2-N

  • SS. Mok
  • et al

Presenilin-1 mutations in Alzheimer's disease

Neurobiol Nature . 2000 Jun 01 ; 405 531 | DOI : https://doi.org/10.1038/35014735

  • C. Russo
  • et al