IMG-EN-AS-29903-01-01.jpg
Peptides

[Pyr11]-beta-Amyloid (11-42)

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  • Cat.Number : AS-29903-01
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    In stock

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Aßs are generated by the proteolytic processing of the amyloid ß-precursor protein (APP). Subsequent cleavage by g-secretase gives rise to Aß (1-40/42) and Aß (11-40/42). Aß (11-40) and Aß (11-42) are major Aß cleavage products generated by BACE.

Specifications

Chemistry
Sequence one letter code
  • Pyr-VHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • Pyr-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Molecular Formula
  • C152H242N40O41S
Molecular Mass/ Weight
  • 3318.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease cases

J Neural Transm . 2010 Jan 01 ; 117(1) 85 | DOI : 10.1007/s00702-009-0314-x

  • O. Wirths

N‐terminal truncated pyroglutamyl β amyloid peptide Aβpy3‐42 shows a faster aggregation kinetics than the full‐length Aβ1‐42.

Biopolymers . 2009 Oct 01 ; 91(10) 861 | DOI : 10.1002/bip.21271

  • C. D'Arrigo

Effect on memory of acute administration of naturally secreted fibrils and synthetic amyloid-beta peptides in an invertebrate model.

Neurobiol Learn Mem . 2007 Oct 24 ; 89(4) 407 | DOI : 10.1016/j.nlm.2007.08.011

  • M. Feld

β-Amyloid is different in normal aging and in Alzheimer disease.

J. Biol. Chem. . 2015 Aug 15 ; 280(40) 34186 | DOI : 10.1074/jbc.M501694200

  • A. Piccini

References

Glu11 Site Cleavage and N-Terminally Truncated Aβ Production upon BACE Overexpression

Biochem . 2002 Feb 08 ; 41(9) 3128 | DOI : https://doi.org/10.1021/bi015800g

  • K. Liu
  • et al