IMG-EN-AS-60804-01.jpg
Peptides

Amylin (1-37), Islet Amyloid Polypeptide, IAPP, human - 1 mg

$378.00
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  • Cat.Number : AS-60804
  • Availability :
    In stock

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Amylin (1-37) also known as Islet Amyloid Polypeptide, IAPP, is a 37-amino acid hormone co-secreted with insulin by beta cells of the pancreas. It contributes to glycemic control. It is a major constituent of protein deposits identified in the Islets of Langerhans of patients with noninsulin-dependent diabetes mellitus.

Specifications

Chemistry
Sequence one letter code
  • KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (Disulfide bridge: 2-7)
Sequence three letter code
  • H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-OH (Disulfide bridge: 2-7)
CAS registry number
  • 121381-06-4
Molecular Formula
  • C165H260N50O56S2
Molecular Mass/ Weight
  • 3904.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Effects of Protein Corona on IAPP Amyloid Aggregation, Fibril Remodelling, and Cytotoxicity.

Scientific Rpt . 2017 May 26 ; 7 2455 | DOI : 10.1038/s41598-017-02597-0

  • EH. Pilkington

Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation.

Biomater Sci . 2017 Feb 28 ; 5(3) 485 | DOI : 10.1039/c6bm00764c

  • M. Wang

The effect of aluminum ion on the aggregation of human islet amyloid polypeptide (11-28)

ABBS . 2017 Mar 20 ; 49(4) 355 | DOI : 10.1093/abbs/gmx015

  • L. Su

Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.

Ann Neurol . 2017 Jul 29 ; 82(2) 208 | DOI : 10.1002/ana.24992

  • H. Ly

References

Human Amylin Actions on Rat Cholinergic Basal Forebrain Neurons: Antagonism of Beta-Amyloid Effects

J Neurophysiol . 2003 Jul 01 ; 89(6) 2923 | DOI : https://doi.org/10.1152/jn.01138.2002

  • J. Jhamandas
  • et al