IMG-EN-AS-24277-01.jpg
Peptides

Somatostatin 14, human, rat, mouse, pig, chicken, frog

$100.00
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  • Cat.Number : AS-24277
  • Availability :
    In stock

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Somatostatin [SST, GHIH (growth hormone-inhibiting hormone) or SRIF (somatotropin release-inhibiting factor)] is a cyclic peptide hormone existing as two isoforms and produced in the pancreas islet, GI tract and the central nervous system. Tetradecapeptide Somatostatin-14 (SRIF-14, the originally identified somatostatin) and the 28-amino acid Somatostatin-28 (SRIF-28) have similar biological activities but differ in their potency. Somatostatins regulate the endocrine system: they inhibit the release of growth hormone in contrast to Growth Hormone Factor (GRF), which stimulates the release of growth hormone. They also inhibit the release of prolactin and thyrotropin, peptide hormones from the pituitary gland and glucagon and insulin from the pancreas. They control the secretion of gut hormones and function as neurotransmitters.

Specifications

Chemistry
Sequence one letter code
  • AGCKNFFWKTFTSC (Disulfide bridge: 3-14)
Sequence three letter code
  • H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH (Disulfide bridge: 3-14)
CAS registry number
  • 38916-34-6
Molecular Formula
  • C76H104N18O19S2
Molecular Mass/ Weight
  • 1638
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, rat, mouse, pig, chicken, frog

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Citations

The use of acetone as a substitute for acetonitrile in analysis of peptides by liquid chromatography/electrospray ionization mass spectrometry.

Rapid Comm Mass Spectrom . 2010 Jan 01 ; 24(1) 6 | DOI : 10.1002/rcm.4352

  • T. Keppel

Gonadotropin releasing hormone (GnRH) and gonadotropin inhibitory hormone (GnIH) in the songbird hippocampus: regional and sex differences in adult zebra finches.

Peptides. . 2013 Mar 29 ; 46 64 | DOI : 10.1016/j.peptides.2013.05.007

  • N. McGuire

Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii

J Biol Chem. . 2008 Aug 07 ; 283(43) 29186 | DOI : 10.1074/jbc.M802366200

  • AJ. O'Donoghue

A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors

J Biomol Screen. . 2008 Jul 25 ; 13(8) 737 | DOI : 10.1177/1087057108321531

  • X. Zhao

References

Duodenal Somatostatinoma Associated with Diabetic Ketoacidosis Presumably Caused by Somatostatin-28 Hypersecretion

J Clin Endocrinol Metab . 2005 Nov 01 ; 90(11) 6310 | DOI : https://doi.org/10.1210/jc.2004-1904

  • D. Kim
  • et al

Molecular cloning of a somatostatin-28 receptor and comparison of its expression pattern with that of a somatostatin-14 receptor in rat brain

PNAS . 1992 Nov 01 ; 89(21) 10267 | DOI : https://doi.org/10.1073/pnas.89.21.10267

  • W. Meyerhof
  • et al