IMG-EN-AS-28244-01.jpg
Peptides

Charybdotoxin - 0.1 mg

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  • Cat.Number : AS-28244
  • Availability :
    In stock

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Charybdotoxin (ChTX) is a Ca2+-activated K+ channel blocker. It depolarizes peripheral T lymphocytes and blocks their mitogen-induced proliferation. ChTX is a highly basic peptide isolated from venom of the scorpion, Leiurus quinquestriatus hebraeus.

Specifications

Chemistry
Sequence one letter code
  • Pyr-FTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS (Disulfide bridge: 7-28, 13-33 and 17-35)
Sequence three letter code
  • Pyr-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser-OH (Disulfide bridge: 7-28, 13-33 and 17-35)
CAS registry number
  • 95751-30-7
Molecular Formula
  • C176H277N57O55S7
Molecular Mass/ Weight
  • 4296.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Scorpion

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Citations

The role of nitric oxide and potassium channels in the effect of adrenomedullin in human internal thoracic arteries.

Regul Pept . 2010 Jan 14 ; 161(1-3) 92 | DOI : 10.1016/j.regpep.2009.12.023

  • Z. Bayram

Coronary endothelial dysfunction and mitochondrial reactive oxygen species in type 2 diabetic mice.

Am J Physiol-Cell Physiol . 2013 Nov 15 ; 305(10) C1033 | DOI : 10.1152/ajpcell.00234.2013

  • Y-E. Cho

RGD peptides induce relaxation of pulmonary arteries and airways via β3-integrins.

FASEB J . 2014 Feb 05 ; 28(5) 2281 | DOI : 10.1096/fj.13-246348.

  • J. Welschoff

Chronic clofibrate administration prevents saline-induced endothelial dysfunction and oxidative stress in young Sprague-Dawley rats.

Clin Invest Med. . 2008 Apr 01 ; 31(2) E62 | DOI : 10.25011/cim.v31i2.3365

  • S. Sankaralingam

EDHF-mediated rapid restoration of hypotensive response to acetylcholine after chronic, but not acute, nitric oxide synthase inhibition in rats.

Eur J Pharmacol . 2006 Jul 05 ; 546(1-3) 120 | DOI : 10.1016/j.ejphar.2006.06.072

  • KM. Desai