IMG-EN-AS-60026-1-01.jpg
Peptides

CDK5 Substrate [PKTPKKAKKL] - 1 mg

$127.00
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  • Cat.Number : AS-60026-1
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    In stock

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The native peptide PKTPKKAKKL is derived from histone H1 peptide sequence that is docked in the active site of cyclin-dependent kinase 5. It is an effective CDK5 substrate (Km = 40 µM).

Specifications

Chemistry
Sequence one letter code
  • PKTPKKAKKL
Sequence three letter code
  • Pro-Lys-Thr-Pro-Lys-Lys-Ala-Lys-Lys-Leu
Molecular Formula
  • C53H99N15O12
Molecular Mass/ Weight
  • 1138.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

S-Nitrosylation activates Cdk5 and contributes to synaptic spine loss induced by β-amyloid peptide

PNAS . 2011 Aug 23 ; 108(34) 14330 | DOI : https://doi.org/10.1073/pnas.1105172108

  • J. Qu

Kinetic Mechanistic Studies of Cdk5/p25-Catalyzed H1P Phosphorylation: Metal Effect and Solvent Kinetic Isotope Effect

Biochemistry . 2010 Jun 15 ; 49(23) 4921 | DOI : 10.1021/bi100244j

  • M. Liu

References

Identification of Substrate Binding Site of Cyclin-dependent Kinase 5

JBC . 1999 Apr 01 ; 274(14) 9600 | DOI : https://doi.org/10.1074/jbc.274.14.9600

  • P. Sharma
  • et al

MAP Kinases and CDKs:  Kinetic Basis for Catalytic Activation

Biochem . 2003 Jan 04 ; 42(4) 849 | DOI : https://doi.org/10.1021/bi0269761

  • J. Lew
  • et al

Identification of substrate binding site of cyclin-dependent kinase 5

J Biol Chem . 1999 Apr 01 ; 274(14) 9600 | DOI : https://doi.org/10.1074/jbc.274.14.9600

  • P. Sharma
  • et al

MAP Kinases and CDKs: Kinetic Basis for Catalytic Activation

Biochemistry . 2003 Jan 04 ; 42(4) 849 | DOI : https://doi.org/10.1021/bi0269761

  • J. Lew