IMG-EN-AS-60435-1-01.jpg
Peptides

Crosstide [GRPRTSSFAEG], 5-FAM labeled

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  • Cat.Number : AS-60435-1
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    In stock

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Crosstide is a peptide analog of glycogen synthase kinase-3 (GSK-3) that functions as a natural substrate for Akt/PKB. It displays similar specificities towards PKBα, PKBβ and PKBγ isoforms. It is also recognized by MAPKAP kinase-1 and p70S6K. The fluorescent and biotinlyated peptides demonstrate similar enzyme activities.

Specifications

Chemistry
Sequence one letter code
  • 5-FAM-GRPRTSSFAEG
Sequence three letter code
  • 5-FAM-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH
Molecular Formula
  • C69H87N17O23
Molecular Mass/ Weight
  • 1522.6
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Drosophila

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References

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

Ann Rev Biochem . 1999 Jul 01 ; 68(1) 965 | DOI : https://doi.org/10.1146/annurev.biochem.68.1.965

  • TO. Chan
  • et al

Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3β) at serine-9 through direct interaction

Biochem Biophys Res Commun . 2002 May 17 ; 293(4) 1191 | DOI : https://doi.org/10.1016/S0006-291X(02)00349-2

  • F. Dai
  • et al

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

JBC . 1997 Nov 01 ; 272(48) 30491 | DOI : https://doi.org/10.1074/jbc.272.48.30491

  • R. Meier
  • et al