PRAME (Preferentially Expressed Antigen of Melanoma), first isolated as a human melanoma antigen recognized by cytotoxic T cells (CTL), is frequently expressed in a variety of cancers. The PRAME gene can be detected in some of the hematological malignancies, neuroblastomas and normal testis. PRAME is a promising marker for detection of minimal residual disease (MRD) in patients with leukemia and a particularly attractive target for immunotherapeutic strategies in neuroblastoma.
Ref: Matsushita, M. et al. Leuk. Lymphoma 44, 439 (2003); Kessler, J. et al. J. Exp. Med. 193, 73 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Leu - Tyr - Val - Asp - Ser - Leu - Phe - Phe - Leu - OH