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Peptides  >  Cell Permeable Peptides (CPP) / Drug Delivery Peptides  >>  Cys(Npys)-(Arg)9

Product Name Cys(Npys) - (Arg)9
C(Npys)RRRRRRRRR - NH2
Size 1 mg
Catalog # AS-61205
US$ $242
Description

This is a peptide comprising of 9 Arginine residues and is synthesized with an activated cysteine residue C(Npys), wherein Npys is 3-Nitro-2-pyridinesulfenyl group protects cysteine. This kind of modification has been used to render this peptide as a carrier peptide applicable in conjugation and cell permable studies. The S(Npys) group of this cysteine-containing 9R is capable of reacting selectively with the free thiol group of another cysteine-containing peptide to form an unsymmetrical disulfide bond. Coupling of sulfhydrils has been studied as an effective means to deliver/release therapeutics such as siRNA in the reducing environment within the cell. For example, in a study leukemic-specific SiRNA was delivered by the formation of immunocomplexes that consisted of targeted antibody conjugated to oligo-9-Arg peptides.

Detailed Information Datasheet
Storage -20C
References Lee KY. et al. Mol & Cells. 29(5):457-462 (2010).
Molecular Weight 1680.1
Sequence
(One-Letter Code)
C(Npys)RRRRRRRRR-NH2
Sequence
(Three-Letter Code)
H - Cys(Nyps) - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - Arg - NH2
     
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