This 14-residue peptide toxin from the wasp venom is originally found as a histamine releaser from mast cells. It induces mitochondrial membrane permeabilization via a CsA-inhibitable mechanism.
Ref: Hori, Y. et al. Eur. J. Biochem. 268, 302 (2001); Hirata, Y. et al. Mol. Pharmacol. 57, 1235 (2000); Yajima, Y. et al. Endocrinol. 138, 1949 (1997); Sukumar, M. et al. Biochem. 36, 3632 (1997); Higashijima, T. et al. J. Biol. Chem. 263, 6491 (1995).
Molecular Weight
1478.9
Sequence (One-Letter Code)
INLKALAALAKKIL-NH2
Sequence (Three-Letter Code)
H - Ile - Asn - Leu - Lys - Ala - Leu - Ala - Ala - Leu - Ala - Lys - Lys - Ile - Leu - NH2