IMG-EN-AS-22859-01.jpg
Peptides

Endothelin 1, human, porcine, bovine, mouse, rat

$180.00
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  • Cat.Number : AS-22859
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    In stock

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ET-1 is a potent vasoconstrictor peptide derived from endothelial cells. It plays a role in regulation of cardiovascular functions. The binding of ET-1 to G-protein coupled receptor triggers a signal transduction cascade leading to activation of the protein kinase C (PKC). PKC inhibitor potentially reverses the up regulation of ET-1. The enhanced ET-1 expression associated with the activation of PKC occurs in early diabetes.

Specifications

Chemistry
Sequence one letter code
  • CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: 1-15 and 3-11)
Sequence three letter code
  • H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Disulfide bridge: 1-15 and 3-11)
CAS registry number
  • 117399-94-7
Molecular Formula
  • C109H159N25O32S5
Molecular Mass/ Weight
  • 2492
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, porcine, bovine, mouse, rat

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Citations

Equal contribution of increased intracranial pressure and subarachnoid blood to cerebral blood flow reduction and receptor upregulation after subarachnoid hemorrhage. Laboratory investigation.

J Neurosurg . 2009 Nov 01 ; 111(5) 978 | DOI : 10.3171/2007.3.16738

  • S. Ansar

Neurogenesis Associated with Endothelin-induced Cortical Infarction in the Mouse

Brain Res . 2008 Sep 05 ; 1167 118 | DOI : 10.1016/j.brainres.2007.06.065

  • Y. Wang

Endothelin-1 Attenuates Apoptosis in Cultured Trophoblasts From Term Human Placentas.

Reprod Sci . 2007 Dec 31 ; 14(5) 430 | DOI : https://doi.org/10.1177/1933719107305801

  • M. Cervar-Zivkovic

ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat.

J Cereb Blood Flow Metab. . 2006 Jun 01 ; 26(6) 846 | DOI : 10.1038/sj.jcbfm.9600236

  • SA. Beg

Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction.

J Neurosurg. . 2007 May 01 ; 106(5) 881 | DOI : 10.3171/jns.2007.106.5.881

References

A Novel Potent Vasoconstrictor Peptide Produced by Vascular Endothelial Cells

Nature . 1988 Mar 31 ; 332 411 | DOI : 10.1038/332411a0.

  • M. Yanagisawa
  • et al