Fibrinolysis Inhibiting Factor - 5 mg
- Cat.Number : AS-24262
- Manufacturer Ref. :
-
Availability :
In stock
This peptide mimics the N terminus of the alpha-chain of fibrin. It binds to the 'a' polymerization pocket in the alpha-chain more tightly than a peptide corresponding to the chain native sequence GPRV. The complex between GPRP and fibrinogen causes an increased resistance to degradation by plasmin, and the polymerization reaction is depressed by the addition of excess peptide. Fibrin assembly, as well as the acceleration of the factor XIIIa reaction, can be prevented by this homologue of the natural sequence of amino acids.
Specifications
| Chemistry | |
| Sequence one letter code |
|
|---|---|
| Sequence three letter code |
|
| CAS registry number |
|
| Molecular Formula |
|
| Molecular Mass/ Weight |
|
| Modification | |
| Conjugation |
|
| Quantity & Purity | |
| Purity |
|
| Storage & stability | |
| Form |
|
| Storage Conditions |
|
| Activity | |
| Biomarker Target | |
| Research Area | |
| Sub-category Research Area | |
| Usage |
|
| Source | |
| Source / Species |
|
Downloads
You may also be interested in the following product(s)
SensoLyte® 520 Thrombin Activity Assay Kit Fluorimetric - 1 kit
SensoLyte® AFC Plasmin Activity Assay Kit Fluorimetric - 1 kit
Citations
Biocompatibility Assessment of the First Generation PediaFlow Pediatric Ventricular Assist Device.
Artificial Organs . 2012 Jan 01 ; 35(1) 9 | DOI : doi:10.1111/j.1525-1594.2010.01023.x.
- C. Johnson
References
The primary fibrin polymerization pocket: Three-dimensional structure of a 30-kDa C-terminal γ chain fragment complexed with the peptide Gly-Pro-Arg-Pro
PNAS . 1997 Jul 08 ; 94(14) 7176 | DOI : https://doi.org/10.1073/pnas.94.14.7176
- K. Pratt
- et al
A double-headed Gly-Pro-Arg-Pro ligand mimics the functions of the E domain of fibrin for promoting the end-to-end crosslinking of γ chains by factor XIIIa
PNAS . 1998 Jan 20 ; 95(2) 537 | DOI : https://doi.org/10.1073/pnas.95.2.537
- L. Lorand
- et al