IMG-EN-AS-61110-01.jpg
Peptides

Cyclo (-GRGDSP)

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  • Cat.Number : AS-61110
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    In stock

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This cyclic peptide is a potent vasodilator. It is more powerful than the linear GRGDSP in changing the vascular tone of arterioles isolated from rat cremaster muscle.

Specifications

Chemistry
Sequence one letter code
  • GRGDSP, N to C cyclized
Sequence three letter code
  • Cyclo(-Gly-Arg-Gly-Asp-Ser-Pro)
Molecular Formula
  • C22H35N9O9
Molecular Mass/ Weight
  • 569.6
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse, rat, human

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Citations

Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells.

J Biol Chem . 2013 Jan 18 ; 288(10) 7410 | DOI : 10.1074/jbc.M112.400259.

  • ML. Burch

Role of fibronectin in topographical guidance of neurite extension on electrospun fibers.

Biomaterials . 2011 Mar 05 ; 32(16) 3958 | DOI : 10.1016/j.biomaterials.2011.02.015.

  • V. Mukhatyar

Demonstration of catch bonds between an integrin and its ligand.

J Cell Biol . 2009 Jun 29 ; 185(7) 1275 | DOI : 10.1083/jcb.200810002

  • F. Kong

Live imagine of collagen remodeling during angiogenesis.

Am J Physiol Heart Circ Physiol . 2007 Feb 16 ; 292(6) H3196 | DOI : 10.1152/ajpheart.01234.2006

  • ND. Kirkpatrick

Integrin-mediated first signal for inflammasome activation in intersital epithelial cells.

J Immunol . 2014 Jun 25 ; 193(3) 1373 | DOI : 10.4049/​jimmunol.1400145

  • J. Thinwa

References

Vascular Smooth Muscle Alpha v Beta 3 Integrin Mediates Arteriolar Vasodilation in Response to RGD Peptides

Circ Res . 1996 Oct 01 ; 79(4) 821 | DOI : 10.1161/01.res.79.4.821.

  • JE. Mogford
  • et al