IMG-EN-AS-24160-01.jpg
Peptides

Ghrelin, rat, mouse Peptide

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  • Cat.Number : AS-24160
  • Availability :
    In stock

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Rat/mouse Ghrelin differs from human Ghrelin on the 11th and 12th position - RV (Arg-Val) in rat/mouse and KA (Lys-Ala) in human. Ghrelin is an appetite stimulating peptide hormone secreted by stomach P/D1-type cells in humans and circulates in the bloodstream during fasting conditions. Enzymatically n-octanoylated Serine3 of this 28-amino acid Ghrelin is the endogenous ligand specific for growth hormone secretagogue receptor 1a (GHSR1a). The GHSR1a receptor appears to be dedicated to Ghrelin and is widely expressed in different tissues.

Specifications

Chemistry
Sequence one letter code
  • GS-S(n-octanoyl)-FLSPEHQKAQQRKESKKPPAKLQPR
Sequence three letter code
  • H-Gly-Ser-[Ser(n-octanoyl)]-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
CAS registry number
  • 258338-12-4
Molecular Formula
  • C147H245N45O42
Molecular Mass/ Weight
  • 3315
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • rat

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Citations

The effects of ghrelin on ovary histology in Barbus sharpeyi.

J Anim Physiol Anim Nutr . 2011 Jan 28 ; 95(5) 599 | DOI : 10.1111/j.1439-0396.2010.01089.x.

  • H. Mabudi

Effects of different feeding programs and ghrelin injection on plasma ghrelin concentrations and distribution of the ghrelin positive cells in the abomasum of Awassi male lambs.

Revue Méd. Vét. . 2011 Jan 01 ; 162(2) 65

  • N. Ozfiliz

Effects of repeated administered ghre3lin on chronic constriction injury of the sciatic nerve in rats.

Neurosci Lett . 2010 Jun 01 ; 479(3) 226 | DOI : 10.1016/j.neulet.2010.05.066

  • E. Guneli

Ghrelin protects against cell death of hippocampal neurons in pilocarpine-induced seizures in rats.

Neurosci Lett . 2009 Jan 30 ; 453(1) 58 | DOI : 10.1016/j.neulet.2009.01.067

  • J. Xu

Exogenous ghrelin modulates release of pro-inflammatory and anti-inflammatory cytokines in LPS-stimulated macrophages through distinct signaling pathways.

Surgery . 2007 Dec 27 ; 43(3) 334 | DOI : 10.1016/j.surg.2007.09.039

  • T. Waseem

Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone.

Cell . 2008 Feb 08 ; 132(3) 387 | DOI : 10.1016/j.cell.2008.01.017

  • J. Yang

Ghrelin enhances in vivo skeletal muscle but not liver AKT signaling in rats.

Obesity . 2007 Nov 01 ; 15(11) 261 | DOI : 10.1038/oby.2007.313

  • R. Barazzoni

Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion.

Chin J Physiol . 2006 Oct 31 ; 49(5) 244 | DOI : PMID: 17294832

  • Y. Liu

Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle.

AJP-Endo Metab . 2004 Aug 24 ; 288(1) E228 | DOI : 10.1152/ajpendo.00115.2004

  • R. Barazzoni

References

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Nature . 1999 Dec 09 ; 402(6762) 656 | DOI : https://doi.org/10.1038/45230

  • M. Kojima
  • et al

Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei

Clin Endo Metab . 2005 Aug 01 ; 289(2) R353 | DOI : https://doi.org/10.1152/ajpregu.00756.2004

  • P. Currier
  • et al

Ghrelin signalling on food reward: a salient link between the gut and the mesolimbic system

J Neuroendocrinol . 2015 Jun 01 ; 27(6) 424 | DOI : 10.1111/jne.12236

  • M. Perello
  • SL. Dickson

Ghrelin: structure and function

Physiol Rev . 2005 Apr 01 ; 85(2) 495 | DOI : https://doi.org/10.1152/physrev.00012.2004

  • M. Kojima
  • K. Kangawa

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

Cell . 2008 Feb 08 ; 132(3) 387 | DOI : https://doi.org/10.1016/j.cell.2008.01.017

  • J. Yang
  • et al