This peptide, also referred to as Buforin II peptide is a 21 amino acid peptide derived from Buforin I peptide that is isolated from the Asian toad Bufo gargarizans. The 21 amino acid peptide has been shown to possess anti-microbial activity by penetrating bacteria and inhibiting cellular functions. In comparison to magainin 2, this peptide binds DNA and RNA from E.coli with a much greater affinity. It is also considered a cell-delivery peptide and has been shown to deliver SiRNAs into cells followed by effective mRNA degradation.
1, Lan Y. et al. Biochim et Biophys Acta. 1798:1934-1943 (2010) 2, Bartz, R. et al. Biochem J. 435(2):475-487 (2011).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
Thr - Arg - Ser - Ser - Arg - Ala - Gly - Leu - Gln - Phe - Pro - Val - Gly - Arg - Val - His - Arg - Leu - Leu - Arg - Lys