Glucagon (1-29), bovine, human, rat, porcine
- Cat.Number : AS-22456
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Glucagon is a peptide hormone secreted from the pancreatic Islet of Langerhans alpha-cells, in response to low circulating blood glucose levels in order to restore normal glucose levels. It acts on hepatic enzymes that regulate glucose production and glycogen synthesis. Excessive amounts of circulating glucagon levels is implicated in the metabolic dysregulation of type 2 diabetes, since such conditions result in hyperglycaemia.
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Citations
Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.
JBC . 2000 Sep 01 ; 275(35) 27274 | DOI : 10.1074/jbc.M003910200
- SRJ. Hoare
References
Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists
Mol Cell Endocrinol . 2013 Dec 05 ; 381(1-2) 26 | DOI : 10.1016/j.mce.2013.07.014
- FP. O'Harte
- et al