IMG-EN-AS-23606-01.jpg
Peptides

Glucagon-Like Peptide 1, GLP-1 (1-36) amide, human, mouse, rat, bovine, guinea pig, FAM-labeled

$440.00
Check your price
  • Cat.Number : AS-23606
  • Availability :
    In production

Size

Alternative choices

Quantity

Add to wishlist Bulk Quote

This is fluorescent GLP-1 labeled at the peptide N-terminus with FAM, Abs/Em=494/521 nm. In response to Glucose ingestion, proglucagon in the intestinal L cells is cleaved into GLP-1 (1-36). Prior to secretion into the circulation, GLP-1 (1-36) is further processed into amidated GLP-1 (7-36)-and small amounts of glycine-extended GLP-1 (7-37). Both GLP-1 (7-36) and GLP-1 (7-37), causes glucose dependent release of insulin by pancreatic beta-cells. They also play a role in gastric motility (gastric emptying), on the suppression of plasma glucagon levels (glucose production) and possibly on the promotion of satiety and stimulation of glucose disposal in peripheral tissues independent of the actions of insulin. GLP-1 peptides such as GLP-1 (1-36) have been used to investigate restoration of pancreatic beta cell function. GLP-1 is also produced in the central nervous system.

Specifications

Chemistry
Sequence one letter code
  • FAM-HDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2
Sequence three letter code
  • FAM-His-Asp-Glu-Phe-Glu-Arg-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Molecular Formula
  • C205H283N51O63
Molecular Mass/ Weight
  • 4470
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

Downloads

You may also be interested in the following product(s)

IMG-EN-AS-24463-01.jpg

Exendin 4

Cat.Number : AS-24463
$290.00 Excl. Tax
IMG-EN-AS-65568-05-01.jpg

GIP, rat

Cat.Number : AS-65568-05
$230.00 Excl. Tax
IMG-EN-AS-72231-01.jpg

SensoLyte® 520 IDE Activity Assay Kit Fluorimetric - 1 kit

Cat.Number : AS-72231
$637.00 Excl. Tax

References

Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line.

PNAS . 1987 May 01 ; 84(10) 3434 | DOI : 10.1073/pnas.84.10.3434

  • D. Drucker
  • et al

The Glucagon-Like Peptides

Endo Rev . 1999 Dec 01 ; 20(6) 876 | DOI : https://doi.org/10.1210/edrv.20.6.0385

  • T. Kieffer
  • et al

Circulation and degradation of GIP and GLP-1

Hormone Metab Res . 2004 Nov 12 ; 36(11-12) 761 | DOI : 10.1055/s-2004-826160.

  • CF. Deacon
  • et al

GLP-1

Pancreadepedia . 2014 May 12 ; | DOI : 10.3998/panc.2014.7

  • JA. Williams
  • et al