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Peptides  >  Cancer Research Peptides  >>  HIF-1 {alpha} (556-574)

Product Name HIF - 1 {alpha} (556 - 574)
DLDLEMLAPYIPMDDDFQL
Size 1 mg
Catalog # 61528
US$ $127
Purity % Peak Area By HPLC ≥ 95%
Description

This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in response to a lack of oxygen. This part of HIF-1 binds to the von Hippel-Lindau factor (VHL) an E3 ubiquitin ligase, and the proline 564 is absolutely critical to the binding process

Storage -20°C
References Ref: Hirsilä, M. et al. J Biol. Chem 278, 30772 (2003); Robinson, B. Pediatric Research 50, 673 (2001).
Molecular Weight 2254.6
Sequence
(One-Letter Code)
DLDLEMLAPYIPMDDDFQL
Sequence
(Three-Letter Code)
H - Asp - Leu - Asp - Leu - Glu - Met - Leu - Ala - Pro - Tyr - Ile - Pro - Met - Asp - Asp - Asp - Phe - Gln - Leu - OH
     
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