This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in response to a lack of oxygen. This part of HIF-1 binds to the von Hippel-Lindau factor (VHL) an E3 ubiquitin ligase, and the proline 564 is absolutely critical to the binding process
Ref: Hirsilä, M. et al. J Biol. Chem 278, 30772 (2003); Robinson, B. Pediatric Research 50, 673 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Asp - Leu - Asp - Leu - Glu - Met - Leu - Ala - Pro - Tyr - Ile - Pro - Met - Asp - Asp - Asp - Phe - Gln - Leu - OH