IMG-EN-AS-61334-01.jpg
Peptides

MUC5AC-3 - 1 mg

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  • Cat.Number : AS-61334
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This glycopeptide is a 16-amino acid modified fragment of mucin 5/MUC5AC, where T* is a GalNac labeled threonine 3. Mucin-type linkages (GalNAc 1-O-Ser/Thr) are initiated by a family of glycosyltransferases known as the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases (ppGaNTases). These enzymes transfer GalNAc from the sugar donor UDP-GalNAc to serine and threonine residues, forming an alpha anomeric linkage. The MUC5AC gene, which is mainly expressed in gastric and respiratory mucosae, exhibits 8 amino acid tandemly repeated domain, the consensus peptide TTSTTSAP.

Specifications

Chemistry
Sequence one letter code
  • GT-T*-PSPVPTTSTTSAP (* = GalNAc-modified residue)
Sequence three letter code
  • H-Gly-Thr-Thr*-Pro-Ser-Pro-Val-Pro-Thr-Thr-Ser-Thr-Thr-Ser-Ala-Pro-OH (Thr* = GalNAc labeled Thr)
Molecular Mass/ Weight
  • 1704.9
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

A UDP-GalNAc:PolypeptideN-Acetylgalactosaminyltransferase Is Essential for Viability in Drosophila melanogaster

J Biol Chem . 2002 Jun 01 ; 277(25) 22616 | DOI : https://doi.org/10.1074/jbc.M201807200

  • K. Ten Hagen
  • et al

All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases

Glycobiol . 2003 Jan 01 ; 13(1) 1R | DOI : https://doi.org/10.1093/glycob/cwg007

  • K. Ten Hagen
  • et al

Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?

Biochem J . 1995 Jan 01 ; 305(1) 211 | DOI : https://doi.org/10.1042/bj3050211

  • V. Duperat
  • et al

Gastrointestinal expression and partial cDNA cloning of murine Muc2

Am J Physiol Gastrointest Liver Physiol . 1999 Jan 01 ; 276(1) G115 | DOI : https://doi.org/10.1152/ajpgi.1999.276.1.G115

  • B. Van Klinken
  • et al