IMG-EN-AS-21006-01.jpg
Peptides

MAPS, Core, 8-Branch - 10 mg

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  • Cat.Number : AS-21006
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Multiple Antigenic Peptides (MAPs) are peptides that are branched artificially, in which Lys residues are used as the scaffolding core to support the formation of =8 branches with varying or the same peptide sequences. It is a method for producing high-titre peptide antibodies and synthetic peptide vaccines. This system utilizes the alpha- and epsilon-amino functional groups of lysine to form a backbone to which multiple peptide chains are attached. Depending on the number of lysine tiers (2, 4, 8, etc.), different numbers of peptide branches can be synthesized. This technology enables successful production of high-titre antibodies. MAPs have a high molar ratio of the peptide antigen to the core molecule, and no carrier protein is needed to elicit an antibody response.

Specifications

Chemistry
Sequence one letter code
  • (K)4-(K)2-K-A
Sequence three letter code
  • H-(Lys)4-(Lys)2-Lys-Ala-NH2
CAS registry number
  • na
Molecular Mass/ Weight
  • 985.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • n/a

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Citations

Interplay between Akt and p38 MAPK Pathways in the Regulation of Renal Tubular Cell Apoptosis Associated with Diabetic Nephropathy.

Am J Physiol Renal Physiol. . 2009 Sep 02 ; 298(1) F49 | DOI : 10.1152/ajprenal.00032.2009

  • J. Rane. Madhavi

References

A novel method for producing anti-peptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain.

J Biol Chem . 1988 Feb 01 ; 263(4) 1719 | DOI : https://doi.org/10.1016/S0021-9258(19)77935-6

  • D. Posnett
  • et al

Long-Term High-Titer Neutralizing Activity Induced by Octameric Synthetic HIV-1 Antigen

Science . 1991 Oct 11 ; 254(5029) 285 | DOI : 10.1126/science.1925584

  • CY. Wang
  • et al

Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system

PNAS . 1988 Aug 01 ; 85(15) 5409 | DOI : https://doi.org/10.1073/pnas.85.15.5409

  • JP. Tam

Synthesis of multiple antigenic peptides (MAPs)—strategies and limitations

J Pept Sci, . 2011 Apr 01 ; 17(4) 247 | DOI : https://doi.org/10.1002/psc.1310

  • W. Kowalczyk
  • et al