Bax BH3 (55-74) - 1 mg
- Cat.Number : AS-62266
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This is a 20–amino acid Bax BH3 peptide (Bax 1) capable of inducing apoptosis in a variety of cell line models. In addition to disrupting Bax/Bcl-2 and Bax/Bcl-XL, it can promote cytochrome c release from isolated mitochondria. Bax BH3 belongs to the Bcl-2 protein family which consists of both pro-apoptotic and anti-apoptotic members. Bax BH3 acts to regulate apoptosis via governance of the 'intrinsic' pathway of cell death.
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References
Peptides Derived from BH3 Domains of Bcl-2 Family Members: A Comparative Analysis of Inhibition of Bcl-2, Bcl-xL and Bax Oligomerization, Induction of Cytochrome c Release, and Activation of Cell Death
Biochem . 2002 Jul 02 ; 41(30) 9485 | DOI : https://doi.org/10.1021/bi025605h
- S. Shangary
- D. Johnson
Sequence and helicity requirements for the proapoptotic activity of Bax BH3 peptides
Mol. Canc. Ther. . 2004 Nov 01 ; 3(11) 1343 | DOI : PubMed 15542773
- S. Shangary
- et al