This 12 amino acids peptide is a hyaluronan inhibitor (HA), a high molecular weight glycosaminoglycan expressed abundantly in the extracellular matrix and on cell surfaces. This peptide shows specific binding to soluble, immobilized, and cell-associated forms of HA, and it inhibits leukocyte adhesion to HA substrates almost completely.
Mummert, M. et al. J. Exp. Med. 192, 769 (2000).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Gly - Ala - His - Trp - Gln - Phe - Asn - Ala - Leu - Thr - Val - Arg - OH