This is a mitogen-activated protein (MAP) kinase substrate, also designated as peptide 4. This peptide is labeled with FAM at the N-terminus. It may be used to determine activation of p38, a member of MAP kinase family which acts as a switch for the transcriptional and translational regulation of a number of proteins, including the proinflammatory cytokines. IPTSPITTTYFFFKKK is also known as an ERK1/2 substrate.
Chen, G. et al. Biochem. 39, 2079 (2000).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
5 - FAM - Ile - Pro - Thr - Ser - Pro - Ile - Thr - Thr - Thr - Tyr - Phe - Phe - Phe - Lys - Lys - Lys - OH