This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.
Vogel, SM. et al. Physiol. Genom. 4:137-145 (2000).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Thr - Phe - Leu - Leu - Arg - Asn - Pro - Asn - Asp - Lys - NH2