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Peptides  >  Thrombin Related Peptides  >>  Protease-Activated Receptor-1, PAR-1 Agonist, amide

Product Name Protease - Activated Receptor - 1, PAR - 1 Agonist, amide
Size 5 mg
Catalog # AS-62937
US$ $193
Purity % Peak Area By HPLC ≥ 95%

This proteinase activated receptor (PAR-1) belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to it's varied cellular effects of thrombin, PAR-1 also has been shown to co-ordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'.

Detailed Information Datasheet
Storage -20C
References 1, Kauffmann, R. et al. Oncol. Rep. 21:1261-1267 (2009).
2, Kirilak, YA. et al. Intl. J. Mol. Med. 17:551-558 (2006).
Molecular Weight 761.9
(One-Letter Code)
(Three-Letter Code)
H - Thr - Phe - Leu - Leu - Arg - Asn - NH2
Product Citations Wang, W. et al. (2009). Kallikrein-related peptidase-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1.Int. J. Cancer 126, 599. doi: 10.1002/ijc.24904.

Mize, G. et al. (2008). Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2. Mol. Cancer. Res 6, 1043. doi: 10.1158/1541-7786.MCR-08-0096.

Su, X. et al. (2005). Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J. Immunol 175, 2598. doi: 10.4049/​jimmunol.175.4.2598.

Kouzaki, H. et al. (2013). Transcription of Interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells J. Resp. Cell. Mol. Biol 49(5):741-750 doi: 10.1165/rcmb.2012-0304OC.
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