IMG-EN-AS-62884-01.jpg
Peptides

Beta-Amyloid (11-25) - 1 mg

$119.00
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  • Cat.Number : AS-62884
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This amino acids 11 to 25 fragment of b-amyloid is capable of forming well-organized amyloid fibrils in vitro, similar to the pathogenic ones found in amyloidosis. Analysis of the structural properties of one monomer of b-amyloid (11-25) as well as of the aggregation mechanisms for four chains of b-amyloid (11-25) showed that the system assembles rapidly into a random globular state that evolves into three- and four-stranded antiparallel beta-sheets. The aggregation process is considerably accelerated by the presence of preformed dimers.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EVHHQKLVFFAEDVG
Sequence three letter code
  • H-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-OH
Molecular Formula
  • C81H119N21O23
Molecular Mass/ Weight
  • 1755.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

A Molecular Model of Alzheimer Amyloid β-Peptide Fibril Formation

J Biol Chem . 1999 Mar 01 ; 274(18) 12619 | DOI : https://doi.org/10.1074/jbc.274.18.12619

  • L. Tjernberg,
  • et al

Aggregating the amyloid Aβ11–25 peptide into a four-stranded β-sheet structure

Proteins . 2006 Dec 01 ; 65 877 | DOI : https://doi.org/10.1002/prot.21134

  • G. Boucher
  • et al