Login
Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Password:
Stay Logged In


Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Recombinant Proteins  >  HIV (Human Immunodeficiency Virus)  >>  HIV-1 Protease, recombinant

Product Name HIV - 1 Protease, recombinant
Size 5 µg
Catalog # 72028-5
US$ $374
Description

The 10-12 kD aspartic protease of human immunodeficiency virus-1 (HIV-1), active only when it forms a homodimer, is required for the post-translational cleavage of the precursor polyproteins, Gag, Gag-Pol, Pol, and Nef. Since the cleavages of precursors are essential for the maturation of HIV infectious particles, this protease is one of the key targets for developing anti-AIDS drugs. The recombinant HIV-1 protease (wild type, NCBI accession: NC_001802) contains the 99 amino acid sequence reported by Schneider, et al., with 6x His-tag at its C-terminal. 50-100 ng of HIV-1 protease is sufficient for FRET-based activity assays (SensoLyte® 490, 520, and 620 HIV Protease Assay Kits, AnaSpec Cat#71127, 71147, 71148) in high throughput drug screening.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
References Seelmeier, S. et al., Proc. Natl. Acad .Sci.USA. 85, 6612-6616 (1988); Schneider, J. and S. B. Kent, Cell 54, 363-368 (1988).
     
  < Back