This peptide is Histone H3 acetylated at lysine 14. Histone lysine aetylation is known to play an important role in chromatin-directed gene transcription. A bromodomain 2 of polybromo (a chromatin remodelling protein) preferentially recognizes acetylated lysine of H3.
1, Borra, MT. et al. Biochem. 43:9877 (2004) 2, Charlop-Powers Z. et al. Cell Res. 20:529-538 (2010)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys(Ac) - Ala - Pro - Arg - Lys - Gln - OH