IMG-EN-AS-63684-01.jpg
Peptides

[Lys(Ac)8]-Histone H4 (1-20) - 1 mg

$221.00
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  • Cat.Number : AS-63684
  • Availability :
    In stock

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This is a histone 4 peptide acetylated at lysine 8. In some studies, this histone modification is thought to predict prognosis of resected non-small-cell lung cancer. This peptide has also been shown to play a role in somatic hypermutation (SHM) possible owing to its modification that likely mediates recruitment of error-prone DNA polymerases at the DNA repair stage of SHM.

Specifications

Chemistry
Sequence one letter code
  • SGRGKGG-K(Ac)-GLGKGGAKRHRK
Sequence three letter code
  • H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys(Ac)-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys-OH
Molecular Mass/ Weight
  • 2034.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Epigenetics of the antibody response

Trends Immunol . 2013 Sep 01 ; 34(9) 460 | DOI : https://doi.org/10.1016/j.it.2013.03.006

  • G. Li
  • et al

Global Histone Modifications Predict Prognosis of Resected Non–Small-Cell Lung Cancer

J Clin Oncol . 2007 Oct 01 ; 25(28) 4358 | DOI : 10.1200/JCO.2007.11.2599

  • F. Barlesi
  • et al

Substrate Specificity and Kinetic Mechanism of the Sir2 Family of NAD+-Dependent Histone/Protein Deacetylases

Biochem. . 2004 Jul 10 ; 43(30) 9877 | DOI : https://doi.org/10.1021/bi049592e

  • MT. Borra
  • et al