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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Lys(Me2)4]-Histone H3 (1-21), H3K4(Me2)

Product Name [Lys(Me2)4] - Histone H3 (1 - 21), H3K4(Me2)
ART - K(Me2) - QTARKSTGGKAPRKQLA
Size 1 mg
Catalog # AS-63677
US$ $225
Purity % Peak Area By HPLC ≥ 95%
Description

This is a dimethylated lysine at position 4 of the 1-21 amino acid histone H3 peptide. This form of histone methylation is characterized as being enriched around transcription start sites (TSS). It has been observed that a subgroup of genes linked to T cell functions showed high levels of H3K4me2 within their gene body. While enrichment for H3K4me2 within the gene body is a characteristic trait of expressed genes in yeast, in contrast, H3K4me2 has been shown to be predominantly enriched around the TSS in mammals.

Detailed Information Datasheet
Storage -20C
References 1, Tian Y. et al. PLOS One. 6(11):e27770 (2011)
2, Pekowska A. et al. Genome Res. 20, 1493-1502 (2010).
Molecular Weight 2282.6
Sequence
(One-Letter Code)
ART-K(Me2)-QTARKSTGGKAPRKQLA
Sequence
(Three-Letter Code)
H - Ala - Arg - Thr - Lys(Me2) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - OH
Product Citations Sakane, C. et al. (2015). Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry. J Clin Biochem Nutr562:123-131. doi: 10.3164/jcbn.14-99.
     
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