IMG-EN-AS-63677-01.jpg
Peptides

[Lys(Me2)4]-Histone H3 (1-21) - 1 mg

$276.00
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  • Cat.Number : AS-63677
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This is a dimethylated lysine at position 4 of the 1-21 amino acid histone H3 peptide. This form of histone methylation is characterized as being enriched around transcription start sites (TSS). It has been observed that a subgroup of genes linked to T cell functions showed high levels of H3K4me2 within their gene body. While enrichment for H3K4me2 within the gene body is a characteristic trait of expressed genes in yeast, in contrast, H3K4me2 has been shown to be predominantly enriched around the TSS in mammals.

Specifications

Chemistry
Sequence one letter code
  • ART-K(Me2)-QTARKSTGGKAPRKQLA
Sequence three letter code
  • H-Ala-Arg-Thr-Lys(Me2)-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu-Ala-OH
Molecular Formula
  • C96H176N36O28
Molecular Mass/ Weight
  • 2282.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry.

J Clin Biochem Nutr . 2015 Feb 13 ; 56(2) 123 | DOI : 10.3164/jcbn.14-99

  • C. Sakane

References

A unique H3K4me2 profile marks tissue-specific gene regulation

Genome Res . 2010 Nov 01 ; 20(11) 1493 | DOI : 20841431

  • A. Pekowska
  • et al

Global Mapping of H3K4me1 and H3K4me3 Reveals the Chromatin State-Based Cell Type-Specific Gene Regulation in Human Treg Cells

PLoS One . 2011 Nov 23 ; 6(11) e27770 | DOI : https://doi.org/10.1371/journal.pone.0027770

  • Y. Tian
  • et al