Beta-Amyloid (11-42) - 1 mg
- Cat.Number : AS-63317-
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This is amino acids 11 to 42 fragment of beta-amyloid. This peptide was detected in Alzheimer disease brains within several principal beta-amyloid variants.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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References
Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging
PNAS USA . 1994 Aug 30 ; 91(18) 8378 | DOI : https://doi.org/10.1073/pnas.91.18.8378
- J. Näslund
- et al