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Peptides  >  MHC related   >>  SmD1 (83119)

Product Name SmD1 (83119)
VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR
Size 1 mg
Catalog # 62746
US$ $341
Purity % Peak Area By HPLC ≥ 95%
Description

This is amino acids 83 to 119 fragment of the SmD1 protein (D1 protein of the Sm proteins), one of the small nuclear ribonucleoproteins of the splicing machinery. It is a major target of the B and T cell autoimmune responses associated with human and murine lupus. T cells that recognize this SmD peptide and provide T cell help for both anti-dsDNA and anti-SmD1 (83119) antibodies were recently identified in lupus-prone NZB/W mice, revealing a new model that may help to explain associations between these autoantibodies.

Storage -20C
References Riemekasten, G. et al. J. Immunol. 173, 5835 (2004).
Molecular Weight 4011.6
Sequence
(One-Letter Code)
VEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR
Sequence
(Three-Letter Code)
H - Val - Glu - Pro - Lys - Val - Lys - Ser - Lys - Lys - Arg - Glu - Ala - Val - Ala - Gly - Arg - Gly - Arg - Gly - Arg - Gly - Arg - Gly - Arg - Gly - Arg - Gly - Arg - Gly - Arg - Gly - Arg - Gly - Gly - Pro - Arg - Arg - OH
     
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