IMG-EN-AS-63323-01.jpg
Peptides

[Arg6]-beta-Amyloid (1-42), English Mutation - 0.5 mg

$330.00
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  • Cat.Number : AS-63323
  • Availability :
    In production

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Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. Among them, the English mutation (H6A) was shown to accelerate the fibril elongation rate without a concomitant increase in the levels of protofibrils.

Specifications

Chemistry
Sequence one letter code
  • DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Molecular Formula
  • C203H316N56O60S
Molecular Mass/ Weight
  • 4533.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

The Tottori (D7N) and English (H6R) Familial Alzheimer Disease Mutations Accelerate Aβ Fibril Formation without Increasing Protofibril Formation

J Biol Chem . 2007 Feb 01 ; 282(7) 4916 | DOI : https://doi.org/10.1074/jbc.M608220200

  • Y. Hori
  • et al