Peptides
[Asn23]-beta-amyloid (1-42), Iowa Mutation - 0.5 mg
$330.00
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- Cat.Number : AS-63705
- Manufacturer Ref. :
-
Availability :
In production
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Several mutations in the beta amyloid precursor gene cause autosomal dominant Alzheimer's Disease in a number of kindreds. The Iowa mutation, where Asp 23 is replaced with Asn, is associated with severe cerebral amyloid beta-protein angiopathy (CAA). The affected individuals share a missense mutation in APP at position 694. The mutated beta-amyloid peptide aggregates more rapidly and forms toxic fibrils.
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