This is amino acids 15 to 23 fragment of the insulin β chain recognized by islet-associated T cells. This peptide is also known as INS. It was used in diabetes studies to assay the IFN-β and IL-17 production by diabetogenic CD4 or CD8 T cells. This peptide stains the INS-reactive CTL clone, but doesn’t stain the splenic CD8+ T cells from NOD or 8.3-TCR-transgenic NOD mice.
Hu, C. et al. J. Clin. Invest. 117, 3857 (2007); Amrani, A. et al. Nature 406, 739 (2000).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Leu - Tyr - Leu - Val - Cys - Gly - Glu - Arg - Gly - OH