IMG-EN-AS-55152-100-01.jpg
Protein

Recombinant rat MOG (1-125)

$249.00
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  • Cat.Number : AS-55152-100
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    In stock
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Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in the central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys

The sequence (Accession #CAE84068) corresponding to the extracellular domain of rat MOG along with a 6x His tag was expressed in E. coli. The recombinant rat MOG (R-rMOG) was purified from urea denatured bacterial lysate using immobilized metal affinity chromatography (IMAC). The molecular mass of the recombinant rat MOG is 14.2 kDa.

Specifications

Chemistry
UniProt number
  • Q63345
Molecular Mass/ Weight
  • 14.2 kDa
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Concentration
  • 1 mg/ml
Purification Method
  • Purified
Purity
  • ≥95% by SDS-PAGE
Storage & stability
Form
  • In solution
Resuspension condition
  • rat MOG must be thoroughly mixed directly with Complete Freund’s Adjuvant (CFA). Do not dilute recombinant rat MOG with buffers that have pH greater than 4.5. Protein will precipitate at pH higher than 4.5
Storage Buffer
  • 25 mM sodium acetate buffer (pH=4.0)
Storage Conditions
  • Store at -80°C. Avoid repeated freeze-thaw cycles.
Activity
Application
Biomarker Target
Specificity
  • rat MOG
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Host
Source / Species
  • rat

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Citations

Laquinimod, a quinoline-3-carboxamide, induces type II myeloid cells that modulate central nervous system autoimmunity

PLOS . 2012 Mar 30 ; 7(3) e33797 | DOI : 10.1371/journal.pone.0033797.

  • U. Schulze-Topphoff