The TCR transgenic model (BDC2.5) mimitope was used in type 1 diabetes (T1D) study. T1D is an autoimmune disease in which T cells mediate damage to pancreatic islet β cells. T1D is caused by autoreactive T cell destruction of insulin-producing cells. BDC2.5 mimotope was utilized to support the study on antigen presentation of antigenic peptides to islet autoantigen-specific T cells.
Hu, C. et al. J. Clin. Invest. 117, 3857 (2007); Martin-Orozco, N. et al. J. Immunol. 171, 6954 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Arg - Thr - Arg - Pro - Leu - Trp - Val - Arg - Met - Glu - OH