Peptides

p53 (17-26), FITC labeled - 1 mg

$276.00
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  • Cat.Number : AS-62386
  • Availability :
    In stock

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This is amino acids 17 to 26 fragment of p53, fluorescent labeled through an LC spacer. This peptide is the Mdm-2 binding domain of p53 known also as p53N. This sequence contains all of the residues that come into contact with the binding domain of Mdm-2. The tumor suppressor protein p53 is important in maintaining genome stability and in preventing cancer development, FITC (Abs/Em=493 nm/517 nm).

Specifications

Chemistry
Sequence one letter code
  • FITC-LC-ETFSDLWKLL-NH2
Sequence three letter code
  • FITC-LC-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-NH2
Molecular Mass/ Weight
  • 1753.1
Properties
Absorbance (nm)
  • 493
Emission (nm)
  • 517
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Cellular Uptake of Exogenous Human PDCD5 Protein

J Biol Chem . 2006 Aug 01 ; 281(34) 24803 | DOI : https://doi.org/10.1074/jbc.M600183200

  • Y. Wang
  • et al

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells

PNAS . 2001 Oct 23 ; 98(22) 12438 | DOI : https://doi.org/10.1073/pnas.211280698

  • M. Kanovsky
  • et al