IMG-EN-AS-61962-01-01.jpg
Peptides

Beta-Amyloid (1-40)-Lys(LC-biotin)-NH2, FAM-labeled - 0.1 mg

$296.00
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  • Cat.Number : AS-61962-01
  • Availability :
    In stock

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This is a 5-FAM labeled ß-Amyloid (1-40). This amidated peptide is also biotinylated on the lysine side chain with 6-aminohexanoate (LC) as a spacer, Ex/Em=490 nm/ 520 nm.

Specifications

Chemistry
Sequence one letter code
  • 5-FAM-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV-K(LC-BIOTIN)-NH2
Sequence three letter code
  • 5-FAM-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Lys(LC-Biotin)-NH2
Molecular Mass/ Weight
  • 5155.1
Properties
Absorbance (nm)
  • 490
Emission (nm)
  • 520
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Mixed dimers of insulin degrading enzyme reveal a Cis activation mechanism.

J Biol Chem . 2011 Feb 22 ; 286(16) 13852 | DOI : 10.1074/jbc.M110.191668.

  • E. Song

Probing the efficacy of peptide-based inhibitors against acid-and zinc-promoted oligomerization of amyloid-β peptide via single-oligomer spectroscopy.

Biophys Chem . 2011 Sep 08 ; 160(1) 12 | DOI : 10.1016/j.bpc.2011.08.006.

  • LR. Powell

Protective role of Cys-178 against the inactivation and oligomerization of human insulin-degrading enzyme by oxidation and nitrosylation.

J Biol Chem . 2009 Oct 06 ; 284(49) 34005 | DOI : 10.1074/jbc.M109.030627.

  • LA. Ralat

Monitoring the earliest amyloid-beta oligomers via quantized photobleaching of dye-labeled peptides.

Anal Biochem . 2008 Jul 19 ; 382(1) 29 | DOI : 10.1016/j.ab.2008.07.011.

  • KD. Dukes

References

Structure of substrate-free human Insulin-degrading Enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.

J Biol Chem . 2007 Jul 05 ; 282(35) 25453 | DOI : 10.1074/jbc.M701590200.

  • H. Im