IMG-EN-AS-64442-025-01.jpg
Peptides

[Lys(Me2)36]-Histone H3 (21-44)-GK(Biotin)

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  • Cat.Number : AS-64442-025
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This is a Histone 3 lysine 36 dimethylated peptide. This peptide has been shown to recruit histone deacetylase complex with nucleosomes and repress transcription. In addition, owing to its epigenetic repressive mark, it allows demethylation by a Jumonji C-domain family member, JMJD5 that functions as a transcription activator by inhibiting HDAC, and regulates cell cycle proliferation.

Specifications

Chemistry
Sequence one letter code
  • ATKAARKSAPATGGV-K(Me2)-KPHRYRPG-GK(Biotin)
Sequence three letter code
  • H-Ala-Thr-Lys-Ala-Ala-Arg-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys(Me2)-Lys-Pro-His-Arg-Tyr-Arg-Pro-Gly-Gly-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 2945.6
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Selective recognition of H3.1K36 dimethylation/H4K16 acetylation facilitates the regulation of all-trans-retinoic acid (ATRA)-responsive genes by putative chromatin reader ZMYND8

J. Biol. Chem. . 2015 Dec 11 ; 291(6) 2664 | DOI : 10.1074/jbc.M115.679985

  • S. Adhikary

References

Histone H3 Lysine 36 Dimethylation (H3K36me2) Is Sufficient to Recruit the Rpd3s Histone Deacetylase Complex and to Repress Spurious Transcription

JBC . 2009 Mar 01 ; 284(12) 7970 | DOI : https://doi.org/10.1074/jbc.M808220200

  • B. Li
  • et al

KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation

PNAS USA . 2010 May 25 ; 107(21) 9671 | DOI : https://doi.org/10.1073/pnas.1000401107

  • DA. Hsia
  • et al