This 1-21 amino acid histone H3 peptide has a trimethylated lysine at position 9. This form of histone methylation is characterized as being enriched around transcription start sites. It has been observed that certain family members of the JMJ enzyme (Jumonji C domain-containing oxygenases) that play a role in regulating the methylation status of histone H3 lysine residues exhibits selectivity towards this peptide.
Tian Y. et al. PLOS One. 6(11):e27770 (2011)
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg - Thr - Lys - Gln - Thr - Ala - Arg - Lys(Me3) - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - OH