Peptides

PLP (180-199) - 1 mg

$141.00
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  • Cat.Number : AS-64635
  • Availability :
    In stock

Quantity

This is amino acids 180-199 fragment of myelin proteolipid protein (PLP). PLP, the most abundant myelin protein of the central nervous system, has been used in multiple sclerosis (MS) studies. MS is a chronic inflammatory demyelinating disease of the CNS.

Specifications

Chemistry
Sequence one letter code
  • WTTCQSIAFPSKTSASIGSL
Sequence three letter code
  • H-Trp-Thr-Thr-Cys-Gln-Ser-Ile-Ala-Phe-Pro-Ser-Lys-Thr-Ser-Ala-Ser-Ile-Gly-Ser-Leu-OH
Molecular Formula
  • C92H144N23O30S
Molecular Mass/ Weight
  • 2085.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse, rat

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References

A Structurally Available Encephalitogenic Epitope of Myelin Oligodendrocyte Glycoprotein Specifically Induces a Diversified Pathogenic Autoimmune Response

J Immunol . 2004 Jul 01 ; 173(1) 600 | DOI : https://doi.org/10.4049/jimmunol.173.1.600

  • F. Bischof
  • et al

Encephalitogenicity of Murine, But Not Bovine, DM20 in SJL Mice Is Due to a Single Amino Acid Difference in the Immunodominant Encephalitogenic Epitope

Neurochem Res . 1997 Apr 01 ; 22 541

  • J. Greer
  • et al

Myelin Proteolipid Protein Forms a Complex with Integrins and May Participate in Integrin Receptor Signaling in Oligodendrocytes

J Neurosci . 2002 Sep 01 ; 22(17) 7398 | DOI : https://doi.org/10.1523/JNEUROSCI.22-17-07398.2002

  • T. Gudz
  • et al