IMG-EN-AS-64624-1-01.jpg
Peptides

[Lys(Me2)20]-Histone H4 (1-23)-GGK(Biotin)-NH2 - 1 mg

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  • Cat.Number : AS-64624-1
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    In stock

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This peptide is Histone H4 amino acid residues 1 to 23. It is dimethylated at lysine 20 with a C-terminal GG linker, followed by a biotinylated lysine. The dimethylation of histone H3 at lysine 20 is needed for Crb2 (fission yeast checkpoint protein) localization, checkpoint function, and cell survival after DNA damage.

Specifications

Chemistry
Sequence one letter code
  • SGRGKGGKGLGKGGAKRHR-K(Me2)-VLR-GGK(Biotin)-NH2
Sequence three letter code
  • H-Ser-Gly-Arg-Gly-Lys-Gly-Gly-Lys-Gly-Leu-Gly-Lys-Gly-Gly-Ala-Lys-Arg-His-Arg-Lys(Me2)-Val-Leu-Arg-Gly-Gly-Lys(Biotin)-NH2
Molecular Mass/ Weight
  • 2856.6
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Di-methyl H4 Lysine 20 Targets the Checkpoint Protein Crb2 to Sites of DNA Damage

J Biol Chem . 2008 Nov 01 ; 283(48) 33168 | DOI : https://doi.org/10.1074/jbc.M806857200

  • N. Greeson
  • et al