This peptide is Histone H3 amino acid residues 1 to 21. It is monomethylated at arginine 2 with a C-terminal GG linker, followed by a biotinylated lysine. The monomethylation of histone H3 at arginine 2 in yeast does not inhibit the methylation of histone H3 at lysine 4, is found throughout the coding region of genes, and is associated with active transcription.
Kirmizis, A. et al. Nat Struct Mol Biol16, 449 (2009).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ala - Arg(Me1) - Thr - Lys - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - Gly - Gly - Lys(Biotin) - NH2