IMG-EN-AS-63359-1-01.jpg
Peptides

5-FAM-PMDM6 - 1 mg

$357.00
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  • Cat.Number : AS-63359-1-
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    In stock

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PMDM6-F is a fluorescent-labeled probe for MDM2-binding assay.

Specifications

Chemistry
Sequence one letter code
  • 5-FAM-(ß-A)-(ß-A)-FM-Aib-pY-(6-Cl-DL-Trp)-E-Ac3c-LN-NH2
Sequence three letter code
  • 5-FAM-ß-Ala-ß-Ala-Phe-Met-*Aib-pTyr-(*6-Cl-DL-Trp)-Glu-*Ac3c-Leu-Asn-NH2 (*Aib: a-aminoisobutyric acid; *6-CI-DL-Trp: 6-chloro-DL-tryptoptophan; *Ac3c: 1-amino-cyclopropanecarboxylic acid)
Molecular Mass/ Weight
  • 1784.3
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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References

Structure-Based Design of Spiro-oxindoles as Potent, Specific Small-Molecule Inhibitors of the MDM2−p53 Interaction

J Med Chem . 2006 May 01 ; 49(12) 3432 | DOI : https://doi.org/10.1021/jm051122a

  • K. Ding
  • et al