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Peptides  >  p53 Peptides  >>  [Lys(Me1)382]-p53 (377-387); p53K382Me1

Product Name [Lys(Me1)382] - p53 (377 - 387); p53K382Me1
TSRHK - K(Me) - LMFKT
Size 1 mg
Catalog # 65123
US$ $275
Purity % Peak Area By HPLC ≥ 95%
Description

This peptide is derived from amino acid residues 377-387 of human p53 tumor suppressor protein, with monomethylation at Lys382. Methylation of p53 at Lys382 inhibits expression of p53 target genes and decreases apoptotic and cell cycle arrest functions of p53. This allows p53-dependent DNA repair without apoptosis. Levels of this peptide decrease in response to DNA damage.

Storage -20C
References Shi, X. et al. Mol Cell 27, 636 (2007).
Molecular Weight 1390.7
Sequence
(One-Letter Code)
TSRHK-K(Me)-LMFKT
Sequence
(Three-Letter Code)
H - Thr - Ser - Arg - His - Lys - Lys(Me) - Leu - Met - Phe - Lys - Thr - OH
     
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