This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.
Bright, R. et al. J Neurosci24, 6880 (2004). Tanaka, M. et al. Circulation110, 194 (2004). Braun, M and D. Mochly-Rosen. J Mol Cell Cardiol35 895 (2003). Chen, L. et al. Proc Natl Acad Sci USA98, 11114 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Phe - Asn - Ser - Tyr - Glu - Leu - Gly - Ser - Leu - OH