IMG-EN-AS-65113-01.jpg
Peptides

[Pro18]-beta-Amyloid (12-28) - 1 mg

$119.00
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  • Cat.Number : AS-65113
  • Availability :
    In stock

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This peptide is derived from Aβ (12-28), which represents a binding site for apolipoprotein E (apoE). ApoE is a genetically inherited risk factor for Alzheimer’s disease that promotes aggregation of toxic Aβ.

Specifications

Chemistry
Sequence one letter code
  • VHHQKLPFFAEDVGSNK
Sequence three letter code
  • H-Val-His-His-Gln-Lys-Leu-Pro-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-OH
Molecular Formula
  • C89H133N25O25
Molecular Mass/ Weight
  • 1953.3
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

A Synthetic Peptide Blocking the Apolipoprotein E/β-Amyloid Binding Mitigates β-Amyloid Toxicity and Fibril Formation in Vitro and Reduces β-Amyloid Plaques in Transgenic Mice

Am J Pathol . 2004 Sep 01 ; 165(3) 937 | DOI : https://doi.org/10.1016/S0002-9440(10)63355-X

  • M. Sadowski
  • et al

Residues 17–20 and 30–35 of beta-amyloid play critical roles in aggregation

J Neurosci Res . 2004 Jan 15 ; 75 162 | DOI : https://doi.org/10.1002/jnr.10859

  • R. Liu
  • et al