This peptide is histone H2B (1-22) phosphorylated at Ser14, followed by a C-terminal GGK linker, with biotinylation on the epsilon side chain of Lys. Phosphorylation at Ser14 is catalyzed by mammalian sterile twenty (Mst)-1 kinase and is associated with double-stranded DNA breaks and apoptotic cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Fernandez-Capetillo, O. et al. J Exp Med199, 1671 (2004); Cheung, W. et al. Cell113, 507 (2003).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Pro - Glu - Pro - Ala - Lys - Ser - Ala - Pro - Ala - Pro - Lys - Lys - Gly - pSer - Lys - Lys - Ala - Val - Thr - Lys - Ala - Gln - Gly - Gly - Lys(Biotin) - OH